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Quantitative image analysis reveals no sexual dimorphism in the cellular dynamics of Drosophila heart tube formation

Perez--Vicente, R.; Balaghi, N.; Fernandez-Gonzalez, R.

2026-04-27 developmental biology
10.64898/2026.04.23.720323 bioRxiv
Show abstract

Congenital heart defects affect females and males differently. Several congenital heart defects arise during the formation of the heart tube, suggesting that heart tube morphogenesis may differ between females and males. We investigated if the fruit fly Drosophila melanogaster displays sexual dimorphisms in the cellular mechanisms of heart tube formation. Quantitative microscopy revealed no differences between females and males in the migration of cardiac progenitors to form the heart tube. Our results suggest that Drosophila do not display sexual dimorphisms in early cardiac development, and support the omission of sex as an experimental variable when investigating Drosophila heart tube morphogenesis.

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