Structural plasticity and enhanced fear extinction following psilocybin in chronically stressed mice
Knox, C. A.; Woodburn, S. C.; Gilbert, A. D.; Schlotzhauer, J. M.; Kwan, A. C.
Show abstract
The classic psychedelic psilocybin elicits long-lasting neural plasticity and behavioral effects, but prior studies largely examined stress-naive animals. Using longitudinal imaging, we show that psilocybin increases dendritic spine density in frontal cortical neurons and facilitates fear extinction after chronic restraint stress, demonstrating psilocybins effects in a translationally relevant mouse model.
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