High-variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum
Choi, S.; Lee, N.; Jeon, H.; Park, J.; Kim, S.; Kim, J.-E.; Shin, J.; Moon, H.; Min, K.; Choi, Y.; Hwangbo, A.; Kim, H.; Choi, G. J.; Lee, Y.-W.; Song, D.-G.; Son, H.
Show abstract
O_LIWD40 is a highly conserved protein domain in eukaryotes, playing a critical role in various cellular process. C_LIO_LIWe conducted genome-wide functional analysis of WD40 genes in Fusarium graminearum--a phytopathogenic fungus that causes severe yield loss and mycotoxin contamination in major cereal crops. C_LIO_LIComprehensive phenome analysis of 119 WD40 gene deletion mutants across 22 distinct phenotypic traits revealed phenotypic divergence within the phenome, establishing a strong correlation between virulence and sexual reproduction. Notably, 21 "core WD40 genes" were identified, offering valuable insights into divergent biological processes. C_LIO_LIPilot interactome studies of Fgwd101 and Fgwd133 provided further insights into their potential pathobiological functions. Our investigation contributes to broadening our knowledge of the biological mechanisms underlying fungal pathogenesis and may assist in the identification of targets for antifungal agents. C_LI
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