Characterization of a chronic UV-induced photoaging mouse model: insights into skin barrier dysfunction, extracellular matrix remodeling, and altered adipogenesis
Bajerova, M.; Sinova, R.; Simek, M.; Lehka, K.; Ovesna, P.; Cepa, M.; Doleckova, I.; Velebny, V.; Nesporova, K.; Kubala, L.
Show abstract
Chronic exposure to ultraviolet (UV) radiation, known as photoaging, accelerates skin aging by inducing molecular, histological, and functional changes. This study established a mouse model using SKH-1 hairless mice to investigate chronic UV-induced photoaging over eight weeks. SKH-1 hairless mice were exposed to a combination of UVA and UVB, and the progression of skin damage was monitored through physical, histological, and molecular parameters, with a focus on erythema, transepidermal water loss, and collagen and hyaluronan (HA) metabolism. Significant reductions in HA content and alterations in DNA repair markers, such as {gamma}H2AX, were observed, highlighting the impact of chronic UV exposure on skin structure and function. Reactive adipogenesis and increased epidermal thickness were noted, reflecting adaptive responses to UV-induced damage. By investigating these parameters over the evaluation period, we provide a comprehensive time-course analysis of the progressive impact of UV-induced photoaging, offering insights into the underlying mechanisms and potential therapeutic targets to prevent or delay photoaging.
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