A stereotyped glial attachment determines the morphology and function of neuronal cilia
Wexler, L. R.; Griffin, B.; Dutta, P.; Sengupta, P.; Kolotuev, I.; Ringstad, N.; Heiman, M. G.
Show abstract
Primary cilia are signaling hubs that influence nearly every aspect of cell physiology. Neuronal primary cilia were recently discovered to interact with glia in the mammalian brain, but how cilia-glia attachments form and what roles they play remain unknown. Here, we find that two C. elegans sensory neurons (URX and BAG) use their primary cilia to attach to a specific glial partner (ILsoL). Through a genetic screen, we find that cilia-glia attachment requires BUG-1, a secreted protein with conserved cell adhesion domains that localizes to the cilia-glia attachment site. In the absence of BUG-1, neuronal cilia are present but fail to attach to the glial cell. We find that loss of cilia-glia attachment alters cilia morphology and disrupts stimulus-evoked calcium dynamics in cilia. We propose that primary cilia not only act as antennae for long-range cell communication, but also form close-range cell attachments that modulate cell signaling.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.