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Exploring Electroencephalography for Chronic Pain Biomarkers: A Large-Scale Benchmark of Data- and Hypothesis-Driven Models

2026-03-06 pain medicine Title + abstract only
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Resting-state electroencephalography (EEG) has been proposed as a scalable source of biomarkers for chronic pain, but its clinical potential remains uncertain. To systematically evaluate this potential, we benchmarked nine modeling strategies, spanning conventional machine learning with handcrafted features to state-of-the-art deep learning. Across 72 configurations of signal representations and model architectures, we trained models to predict self-reported pain intensity, using chronological a...

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