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NIR autofluorescence allows for pituitary gland detection during surgery: the first evidence from microscopic studies and in vivo measurements
2026-03-06
surgery
Title + abstract only
View on medRxiv
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A critical challenge in endocrine neurosurgery is intraoperative discrimination between normal pituitary tissue and pituitary neuroendocrine tumors (PitNETs). Suggesting the universal persistence of near-infrared autofluorescence (NIRAF) in endocrine organs and inspired by routine clinical use of NIRAF for parathyroid gland identification, we discovered that pituitary NIRAF can be employed for label-free transsphenoidal surgery guidance. Ex vivo confocal spectral imaging of 33 specimens identifi...
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