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Stability of Microbiome-Derived Fatty Acids in Self-Collected Samples: A Comparative Evaluation of Stool and Blood Matrices

2026-03-06 gastroenterology Title + abstract only
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Background Short-chain fatty acids (SCFAs) are widely used as functional readouts of gut microbial activity in vivo. The growing adoption of decentralised study designs and self-collection protocols has amplified the need for reliable room-temperature storage and shipment strategies. However, SCFAs volatility and the persistence of post-collection microbial metabolism raise concerns regarding pre-analytical stability and the interpretability of measured concentrations. Methods We assessed the te...

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