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Large-Scale Pharmacokinetic Reconstruction of Propofol Effect-Site Concentrations: Quantifying the Divergence between Clinical Titration and Age-Dependent Pharmacodynamic Requirements
2026-03-05
anesthesia
Title + abstract only
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BackgroundPropofol dosing guidelines recommend age-based reductions because hypnotic sensitivity increases in older adults. Most real-world evaluations of induction practice, however, have relied on total weight-normalized dose (mg/kg) rather than estimating cerebral exposure using pharmacokinetic models. Because age-related pharmacokinetic changes alter the relationship between administered dose and peak effect-site concentration (Ce,max), mg/kg surrogates may misrepresent true age-dependent ex...
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