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Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques

Barroso-Batista, J.; Campbell, C. R.; Simons, N. D.; Maurizio, P.; Aguirre-Gamboa, R.; Dumaine, A.; Shiratori, M.; Mondragon, T.; Brandolino, C.; Michopoulos, V.; Tung, J.; Barreiro, L. B.

2026-03-05 genomics
10.64898/2026.03.03.709117 bioRxiv
Show abstract

Social gradients are consistently associated with variation in health outcomes, including infectious disease. However, distinguishing between social gradients in antigen exposure versus social gradients in susceptibility remains challenging. Here, we use a nonhuman primate model for chronic social stress to investigate how social status affects the influenza vaccine-induced adaptive immune response. We first manipulated the social status of female rhesus macaques and then tested the response to influenza antigens in naive individuals and after secondary exposure. Higher social status at the time of first exposure, but not at the time of secondary exposure, predicted stronger antibody responses to both exposures. Social status also drove gene expression differences in adaptive immune pathways, and genes that predicted the magnitude of the antibody response overlapped with those linked to social status. Thus, social gradients shape the adaptive immune response in a temporally dependent manner, with particular sensitivity at the time of initial antigen exposure.

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