Cytotoxic and regulatory CD8 T cells dynamics underlies ICI-myotoxicity outcome
Wang, R.; Xiang, C.; Procureur, A.; Sanchez-Dal Cin, J.; Hong, S.-m.; Zhang, B.; Lin, X.; Lian, X.; Liu, G.; Wu, W.; Chen, X.; Xiao, X.; Chen, X.; Wang, X.; Rosenzwajg, M.; Allenbach, Y.; Fu, Q.; Shen, N.; Salem, J.-E.; Ye, S.
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Immune checkpoint inhibitor-induced myotoxicity (ICI-M) comprises myocarditis, myositis, and myasthenia gravis-like syndrome, demanding rapid recognition and therapy. Using immunophenotyping and transcriptomics analysis from blood and muscle, we identified distinct CD38hi and KIR+ CD8 T cells in ICI-M. Abatacept rescued patients and altered the composition and clonality of these cells. Dynamics of CD38hi and KIR+ CD8 T cells effectively supported therapeutic monitoring, offering personalized treatment in life-threatening irAEs.
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