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Massively parallel functional profiling identifies CCDC88C as a risk gene for ER-positive breast cancer

2026-03-03 genetic and genomic medicine Title + abstract only
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Genome wide association studies (GWAS), combined with fine-mapping have identified 196 independent signals associated with breast cancer risk. Deciphering the functional basis of these associations can inform our understanding of the biology and aetiology of breast cancer. Decoding GWAS risk associations is challenging due to linkage disequilibrium between variants and because most variants map to non-coding regions, influencing breast cancer risk via cis-regulatory mechanisms that modulate the ...

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