Back
Top 2%
21.7%
Top 62%
8.8%
Top 1%
7.6%
Top 5%
5.8%
Top 57%
4.9%
Top 0.3%
3.8%
Top 0.8%
3.8%
Top 0.5%
3.8%
Top 0.1%
3.8%
Top 3%
1.9%
Top 15%
1.9%
Top 3%
1.9%
Top 7%
1.5%
Top 0.3%
1.5%
Top 5%
1.3%
Top 2%
1.3%
Top 11%
1.3%
Top 5%
1.3%
Top 13%
1.1%
Top 0.5%
1.1%
Top 4%
0.9%
Top 2%
0.9%
Top 7%
0.9%
Top 6%
0.9%
Top 4%
0.7%
Top 3%
0.7%
Top 15%
0.7%
Top 25%
0.7%
Top 15%
0.7%
Top 13%
0.7%
Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State
2026-03-06
allergy and immunology
Title + abstract only
View on medRxiv
Show abstract
RIG-I is a cytosolic immune receptor that provides the first line of defense by detecting viral RNA and triggering antiviral responses. Its physiological role in humans remains unclear, as no patients with complete RIG-I deficiency have yet been reported. We identified a critically ill COVID-19 patient with severe RIG-I deficiency caused by heterozygous RIG-I G731R, a novel dominant loss-of-function variant. The G731R mutation in helicase motif VI disrupts the arginine finger, impairing the ATPa...
Predicted journal destinations
1
Nature Communications
483 training papers
2
PLOS ONE
1737 training papers
3
Frontiers in Immunology
140 training papers
4
eLife
262 training papers
5
Scientific Reports
701 training papers
6
The Journal of Immunology
19 training papers
7
Journal of Clinical Investigation
50 training papers
8
Cell Reports Medicine
49 training papers
9
Cell
28 training papers
10
iScience
74 training papers
11
Clinical Infectious Diseases
219 training papers
12
Nature Medicine
88 training papers
13
Journal of Medical Virology
95 training papers
14
Science Immunology
15 training papers
15
Cell Genomics
34 training papers
16
Communications Biology
36 training papers
17
The Journal of Infectious Diseases
137 training papers
18
JCI Insight
63 training papers
19
Proceedings of the National Academy of Sciences
100 training papers
20
npj Vaccines
18 training papers
21
European Respiratory Journal
44 training papers
22
Cell Reports
25 training papers
23
Genome Medicine
56 training papers
24
Science
46 training papers
25
Science Translational Medicine
40 training papers
26
mBio
34 training papers
27
Vaccines
131 training papers
28
Frontiers in Medicine
99 training papers
29
Heliyon
57 training papers
30
eBioMedicine
82 training papers