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Potassium-competitive acid channel blockers versus Proton-Pump inhibitors in the prevention of post-endoscopic peptic ulcer rebleeding: A systematic review and meta-analysis

2026-03-06 gastroenterology Title + abstract only
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Introduction Vonoprazan, a new oral potassium-competitive acid blocker (PCAB), has shown promise in terms of superior acid suppression when compared to Proton pump inhibitors (PPIs). We evaluated the efficacy of PCABs versus PPIs in preventing rebleeding in high-risk peptic ulcer patients after endoscopic hemostasis. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines, we conducted a comprehensive search for relevant studies across Medline...

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