Back
Top 0.7%
23.2%
Top 0.6%
12.4%
Top 18%
8.2%
Top 0.3%
6.2%
Top 2%
5.3%
Top 4%
4.4%
Top 3%
4.4%
Top 85%
4.0%
Top 4%
2.9%
Top 8%
2.9%
Top 79%
2.0%
Top 3%
2.0%
Top 0.7%
1.6%
Top 1%
1.4%
Top 10%
1.4%
Top 10%
1.4%
Top 1%
1.2%
Top 4%
1.2%
Top 10%
1.2%
Top 6%
0.7%
Top 7%
0.7%
Top 16%
0.7%
Top 13%
0.5%
Stage Slip from Diagnostic Latency in MCED Trials: A Calibrated Monte Carlo Reconstruction of the NHS-Galleri Results
2026-03-03
oncology
Title + abstract only
View on medRxiv
Show abstract
BackgroundThe NHS-Galleri trial reported a substantial reduction in Stage IV cancer diagnoses and a four-fold increase in cancer detection rates, but did not meet its primary endpoint of reducing combined Stage III+IV diagnoses in a prespecified group of 12 cancers. We hypothesize that stage slip-- progression of cancers from Stage I/II to Stage III during diagnostic workup--is the primary mechanism behind this statistical masking. MethodsWe developed a Monte Carlo simulation of 142,000 partici...
Predicted journal destinations
1
Nature Communications
483 training papers
2
eLife
262 training papers
3
BMJ Open
553 training papers
4
British Journal of Cancer
22 training papers
5
Clinical Cancer Research
22 training papers
6
Cancers
57 training papers
7
JAMA Network Open
125 training papers
8
PLOS ONE
1737 training papers
9
Frontiers in Oncology
34 training papers
10
BMC Medicine
155 training papers
11
Scientific Reports
701 training papers
12
Cancer Medicine
17 training papers
13
International Journal of Cancer
18 training papers
14
Journal of Clinical Epidemiology
29 training papers
15
Proceedings of the National Academy of Sciences
100 training papers
16
PLOS Medicine
95 training papers
17
Trials
24 training papers
18
BMC Cancer
21 training papers
19
PLOS Computational Biology
141 training papers
20
Communications Medicine
63 training papers
21
Genetics in Medicine
57 training papers
22
Nature Medicine
88 training papers
23
Nature
58 training papers