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Sex as Evolutionary Feedback Loop: synonymous-site conservation and stabilizing compatibility

Prager, M.

2026-03-02 evolutionary biology
10.64898/2026.02.26.708324 bioRxiv
Show abstract

Sexual reproduction has a signal problem. Every organism is the product of millions of interacting components, and distinguishing what is working from what is merely present is extraordinarily difficult when you only have one genomes worth of data. We propose that sex evolved, in part, to solve this: by combining two independently sampled genomes each generation, sexual reproduction runs a population-wide comparison. The more a sequence feature is shared between unrelated individuals, the more likely it is genuinely functional. That comparison creates selection pressure for stability at the most-matched sites --- a conserved compatibility layer, "genomic firmware," that locks in what works while leaving everything else free to vary. We call this flexible determinism. To test whether that firmware layer leaves a measurable footprint, we used a mammalian compendium of fourfold-degenerate (4D) synonymous sites and asked whether splicing- and regulation-linked annotations predict conservation (PhyloP) [1] beyond a strengthened sequence-context baseline that includes 3-mer context and codon identity, with held-out chromosome validation. A bootstrap confidence interval on held-out {Delta}R{superscript 2} = 0.129 [95% CI: 0.127, 0.131] across four independent chromosomes confirms this is not a sampling artifact. But predictive performance alone only shows that mechanistic annotations track conservation. If active purifying selection is culling sites that fail the compatibility test, high-firmware transcripts should show not just higher mean conservation but a narrower distribution --- selection removes outliers at both tails, not just shifts the mean. High-firmware transcripts show a 34% monotonic compression of conservation score variance across deciles (SD: 4.08 [->] 2.68, Wilcoxon p = 2.4x10-{superscript 1}{superscript 1}), the signature predicted by active purifying selection culling the tails of the conservation distribution. Gene Ontology enrichment completes the picture: high-firmware genes concentrate in core cytoplasmic and metabolic machinery; low-firmware genes enrich for neuronal differentiation, synaptic signaling, and ion transport --- the parts of the genome that must work in every background versus the parts that are meant to vary. A phylogenetic control in Drosophila melanogaster confirms the signal holds in insects. The definitive falsification test ---a direct sexual--asexual sister-clade comparison --- remains to be done.

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