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Rare Coding Variant Associations With Primary Open-Angle Glaucoma In African Ancestry:A Multi-Cohort Exome-Wide Meta Analysis
2026-02-27
ophthalmology
Title + abstract only
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Primary open-angle glaucoma (POAG) disproportionately affects individuals of African ancestry, yet rare coding variation in this population remains understudied. To address this gap, we performed a multi-cohort exome-wide meta-analysis across POAAGG, PMBB, All of Us, and UK Biobank, including 4,815 POAG cases and 22,922 controls of genetically inferred African ancestry. Although no gene reached exome-wide significance, we identified several suggestive gene-level associations driven by rare varia...
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