The gene ivory:mir-193 controls scale type differentiation in Heliconius butterflies
Hanly, J. J.; Camino, L.; Loh, L. S.; Livraghi, L.; Gilbert, L. E.; Wray, G. A.; Martin, A.; McMillan, W. O.; Holder, J. C.; Calderon-Onate, P.; Stroh, E. D.; Wagh, P. R.; Arias, C. F.; Ruiz-Moreira, J.; Zhao, L.
Show abstract
The ivory:mir-193 locus is a genetic hotspot underlying melanic wing pattern variation across Lepidoptera, acting as a master regulator of melanic scale fate. This includes the genus Heliconius, where aposematic mimicry is driven by three scale cell types: light Type I, dark-melanic Type II, and red Type III scales. We tested functions of ivory:mir-193 in Heliconius using CRISPR-induced somatic mosaic knockouts of ivory and mir-193 across multiple pattern morphs. Knockouts converted Type II scales to Type I scales. Effects on Type III scales varied among and within individuals, indicating that ivory:mir-193 is permissive for Type III development. Using single-nucleus RNA-seq, we profiled the transcriptional landscape of H. melpomene-{Delta}78k mutants lacking mir-193. Loss of mir-193 produced readthrough transcription, consistent with a model where miR-193 acts as a co-transcriptional terminator. These data show that ivory drives wing pattern variation, while mir-193 mediates downstream diversity in scale fate across Lepidoptera.
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