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Leveraging genome-wide effects on gene expression to identify disease-critical genes with trans-genetic components
2026-02-25
genetic and genomic medicine
Title + abstract only
View on medRxiv
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Genome-wide association studies (GWAS) have implicated tens of thousands of genetic variants associated with complex traits and polygenic diseases. Colocalizing GWAS variants with variants that may regulate gene expression, via expression quantitative trait loci (eQTL) mapping, has successfully led to the identification of disease-critical genes and their cell types of action. Recent studies predominantly colocalize proximal cis-eQTLs, which are estimated to regulate [~]10% of variance in gene e...
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