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Multimodal Deep Learning for Structural Heart Disease Prediction from ECG and Clinical Data

Ajadi, N. A.; Afolabi, S. O.; Adenekan, I. O.; Jimoh, A. O.; Ajayi, A. O.; Adeniran, T. A.; Adepoju, G. D.; Hassan, N. F.; Ajadi, S. A.

2026-02-24 cardiovascular medicine
10.64898/2026.02.22.26346793 medRxiv
Show abstract

This research presents multimodal deep learning for structural heart disease prediction. We evaluated multiple deep learning architectures, including TCN, Simple CNN, ResNet1d18, Light transformer and Hybrid model. The models were examined across the three seeds to ensure robustness, and bootstrap confidence interval is used to measure performance differences. TCN consistently outperforms other competing architectures, achieving statistically significant improvements with stable performance across runs. Similarly in predictive analysis, TCN has efficient computation and stable training compared to all competing architectures. Our results show that TCN emphasizes fairness evaluation when developing deep learning models for healthcare applications.

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