Back
Top 0.8%
22.9%
Top 2%
8.1%
Top 3%
6.6%
Top 2%
6.6%
Top 78%
5.8%
Top 2%
5.2%
Top 62%
4.3%
Top 0.6%
4.0%
Top 4%
4.0%
Top 2%
4.0%
Top 2%
3.3%
Top 6%
2.0%
Top 6%
2.0%
Top 2%
2.0%
Top 3%
1.6%
Top 1%
1.6%
Top 3%
1.4%
Top 5%
1.2%
Top 2%
1.2%
Top 1%
1.0%
Top 6%
0.7%
Top 24%
0.5%
A unifying functional dichotomy organises breast cancer molecular landscape, resolves PIK3CA ambiguity, and supports tiered tumour classification
2026-03-02
oncology
Title + abstract only
View on medRxiv
Show abstract
Clinical interpretation of breast cancer sequencing is constrained not by a lack of data but by the absence of an organising framework that translates constellations of co-occurring mutations and copy-number alterations into tumour-level biology with prognostic and therapeutic meaning. This challenge is exemplified by PIK3CA, a clinically actionable alteration often treated as a single-label biomarker despite context-dependent associations with outcome. We analysed >5,000 breast tumours across m...
Predicted journal destinations
1
Nature Communications
483 training papers
2
eLife
262 training papers
3
Cancers
57 training papers
4
Nature Genetics
72 training papers
5
PLOS ONE
1737 training papers
6
Clinical Cancer Research
22 training papers
7
Scientific Reports
701 training papers
8
BMC Cancer
21 training papers
9
Frontiers in Oncology
34 training papers
10
Proceedings of the National Academy of Sciences
100 training papers
11
British Journal of Cancer
22 training papers
12
The American Journal of Human Genetics
77 training papers
13
PLOS Computational Biology
141 training papers
14
iScience
74 training papers
15
Cancer Medicine
17 training papers
16
Communications Medicine
63 training papers
17
Journal of Clinical Investigation
50 training papers
18
Nature
58 training papers
19
Communications Biology
36 training papers
20
Cell Reports
25 training papers
21
Cell Reports Medicine
49 training papers
22
Nature Medicine
88 training papers