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Quantifying bias from reverse causation in observational studies of dementia risk factors: A simulation study informed by age-specific reverse Mendelian Randomization

2026-02-23 epidemiology Title + abstract only
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BackgroundThe long preclinical phase of dementia can bias estimated effects of baseline exposures on dementia incidence. We demonstrate simulations informed by reverse Mendelian randomization (MR) findings to quantify the age-specific magnitude of reverse causation bias in analyses in observational studies of the effects of body mass index (BMI) on dementia. MethodsWe simulated longitudinal trajectories of BMI and dementia risk from ages 45 to 90 years, calibrating to published evidence on age-...

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