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SPLASH: A Benchtop Platform for Accessible Ultrasensitive Quantification of Plasma Biomarkers in Alzheimer's Disease

2026-02-25 neurology Title + abstract only
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Blood-based biomarkers have emerged as a promising tool for the detection and monitoring of neurodegenerative diseases such as Alzheimers disease (AD), yet broad implementation of ultrasensitive protein quantification remains constrained by reliance on specialized instrumentation and centralized laboratory infrastructure. Here we present SPLASH (Solid Phase Ligation Assay with Single wasH), an ultrasensitive proximity ligation assay platform that achieves sub-pg/mL sensitivity using only standar...

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