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Integrated Inflammatory and Epigenetic Signatures in Peripheral Blood Mononuclear Cells Reveal Novel Mechanisms of Valvular Heart Disease-Associated Atrial Fibrillation

2026-02-23 cardiovascular medicine Title + abstract only
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BackgroundThe molecular drivers distinguishing valvular heart disease-associated atrial fibrillation (VHD-AF) from other AF etiologies remain poorly defined, with prior transcriptomic studies largely focused on non-valvular AF. MethodsWe performed RNA sequencing on peripheral blood mononuclear cells (PBMCs) from 15 patients with VHD-AF and 15 age- and sex-matched healthy controls. Bioinformatic analyses identified differentially expressed genes (DEGs), enriched pathways, and protein-protein int...

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