Back

Integrated metabolomics and genetic analyses reveal loss of protective docosahexaenoic acid as a key driver linking ultra-processed food to Crohn's disease risk

2026-02-22 gastroenterology Title + abstract only
View on medRxiv
Show abstract

ObjectivesTo characterize ultra-processed food (UPF) circulating metabolic signatures associated with Crohns disease (CD) and to localize key metabolic mediators linking UPF intake to CD risk. DesignProspective cohort study. SettingTwo large multi-center cohorts (UK Biobank [UKB] and Whitehall II [WHII] study) across the UK and an Eastern multi-center cohort ONE-IBD Study from China. ParticipantsUK Biobank discovery cohort (n=10,229) for signature derivation, internal validation cohort (n=91,...

Predicted journal destinations

1
American Journal of Gastroenterology
15 training papers
Top 0.5% 8.7%
2
Gut Microbes
15 training papers
Top 0.1% 7.6%
3
Scientific Reports
701 training papers
Top 41% 6.2%
4
Nature Communications
483 training papers
Top 17% 6.2%
5
Gut
17 training papers
Top 0.4% 6.2%
6
Nature Genetics
72 training papers
Top 2% 6.2%
7
eLife
262 training papers
Top 6% 5.8%
8
BMC Medicine
155 training papers
Top 3% 4.9%
9
PLOS ONE
1737 training papers
Top 82% 4.9%
10
Frontiers in Pharmacology
27 training papers
Top 1% 1.9%
11
mSystems
16 training papers
Top 0.3% 1.9%
12
Cell Reports Medicine
49 training papers
Top 2% 1.9%
13
iScience
74 training papers
Top 3% 1.9%
14
Frontiers in Immunology
140 training papers
Top 8% 1.5%
15
eBioMedicine
82 training papers
Top 4% 1.5%
16
JCI Insight
63 training papers
Top 5% 1.3%
17
npj Genomic Medicine
18 training papers
Top 2% 1.3%
18
Nature Medicine
88 training papers
Top 8% 1.3%
19
Nutrients
43 training papers
Top 3% 1.3%
20
Environmental Research
36 training papers
Top 2% 1.3%
21
Frontiers in Medicine
99 training papers
Top 16% 1.1%
22
PLOS Medicine
95 training papers
Top 14% 1.1%
23
Biomedicines
21 training papers
Top 2% 0.9%
24
Cell Genomics
34 training papers
Top 7% 0.7%
25
Proceedings of the National Academy of Sciences
100 training papers
Top 21% 0.7%