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Interactive exploration of biobank-scale ancestral recombination graphs with Lorax.

Katte, P.; Corbett-Detig, R.

2026-02-24 genomics
10.64898/2026.02.19.706861 bioRxiv
Show abstract

Ancestral Recombination Graphs (ARGs) underpin analyses of natural selection, disease association, and population history but remain difficult to explore at biobank scale. We introduce Lorax, a GPU-accelerated, web-native platform for real-time visualization of population-scale ARGs. Lorax integrates genomic position, coalescent time, local genealogy, and metadata, enabling interactive exploration of ancestry and variant inheritance in biobank-scale datasets.

Published in Bioinformatics (predicted rank #1) · training set

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