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Decoding Pathogenic and Resilient Gene Regulatory Interactions in Alzheimer's Disease

2026-02-26 genetic and genomic medicine Title + abstract only
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The molecular basis of cognitive resilience in Alzheimers disease (AD), wherein individuals harbor substantial neuropathology yet maintain cognition, remains poorly understood. To systematically decode the regulatory logic underlying divergent cognitive outcomes, we constructed the largest cell-type-resolved gene regulatory network (GRN) atlas of AD to date, profiling 1.7 million nuclei from 687 individuals classified as Controls, cognitively Resilient, or AD dementia across 27 cell types in the...

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