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Triglyceride Polygenic Score Identifies Differential Bleeding and Cardiovascular Risk with Aspirin in Primary Prevention

2026-02-25 genetic and genomic medicine Title + abstract only
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AimsLow-dose aspirin is no longer routinely recommended for primary prevention in older adults because bleeding risks outweigh cardiovascular benefits. We aimed to investigate whether polygenic scores (PGSs) could modify the effects of aspirin on major bleeding and major adverse cardiovascular events (MACE) in a trial of older individuals. MethodsWe conducted post-hoc genetic analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) randomized, placebo-controlled trial in Australia and...

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