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Large-Scale Multi-Omics Enhance Risk Prediction for Type 2 Diabetes

2026-02-20 epidemiology Title + abstract only
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IntroductionPolygenic risk scores (PRS), metabolomics, and proteomics have each shown promise in improving type 2 diabetes risk prediction, but their combined utility beyond established clinical models remains unclear. We aimed to evaluate whether integrating multi-omics biomarkers enhances 10-year type 2 diabetes risk prediction beyond single-omics extensions and the clinical Cambridge Diabetes Risk Score (CDRS), which includes HbA1c measurements. MethodsWe analysed data from 23,325 UK Biobank...

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