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Balanced deep learning on multi-omics networks identifies molecular subgroups of pathological brain aging

2026-02-19 neurology Title + abstract only
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BackgroundNeurodegenerative diseases, including Alzheimers disease (AD), exhibit substantial clinical and molecular heterogeneity, complicating accurate diagnosis and development of effective therapies. Although multi-omics profiling provides unprecedented molecular resolution, systematic integration of high-dimensional, imbalanced data modalities with disease-relevant biological networks remains a methodological challenge. MethodsWe developed a network-informed multi-omics integration framewor...

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