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Development and Internal Validation of the AB-IPI using Bootstrapping: A Clinicopathological Prognostic Score Integrating Host Fitness and Tumor Biology in Diffuse Large B-Cell Lymphoma
2026-02-19
hematology
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ObjectivesThe therapeutic efficacy of rituximab has reduced the discriminatory power of the International Prognostic Index (IPI) in diffuse large B-cell lymphoma (DLBCL), particularly within intermediate-risk categories. To address this "risk dilution," we aimed to develop and internally validate the AB-IPI (Albumin-BCL2 Refined Prognostic Index) using a hypothesis-driven approach that integrates tumor burden, host fitness, and tumor biology. MethodsThis multi-center retrospective study analyze...
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