Direct effector recognition by a tandem kinase triggers non-canonical immunity in wheat
Lemmer, C.; Annan, E. N.; Schwessinger, B.; Pereira, E.; Dagvadorj, B.; Xiao, D.; Wulff, B. B. H.; Krattinger, S. G.; Kwan, A.; Abduljalil, J. M.; Singh, S.; Ho, T. N.; Kaiser, B. N.; Lagudah, E.; Park, R. F.; Zhang, P.; Huang, L.; Ding, Y.
Show abstract
Tandem kinase proteins (TKPs) are an important class of disease resistance genes in cereal crops alongside nucleotide-binding (NB-ARC) leucine-rich repeat (LRR) (NLR) receptors. Here, we cloned the wheat (Triticum aestivum) resistance gene Lr41, which encodes a TKP with a C-terminal fusion, and its paired effector gene AvrLr41 from the rust pathogen Puccinia triticina. AvrLr41 is unusually large and highly divergent from most fungal effectors and is directly recognized by Lr41 through its pseudokinase domain. Immune activation mediated by Lr41 require auxiliary helper proteins, including either a minimal coiled-coil (CC) helper protein or its full-length NLR ortholog. These findings reveal a non-canonical immune system in which a kinase-type receptor directly recognizes an effector and recruits either CC or NLR helpers, demonstrating that full-length NLRs are not strictly required for NLR-linked immune execution and expanding the functional repertoire of disease resistance proteins in crops.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity 97%
- Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis 97%
- CRISPR targeting of H3K4me3 activates gene expression and unlocks centromere-proximal crossover recombination in Arabidopsis 96%
Similar papers in this journal
- S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs 96%
- Bioengineering a plant NLR immune receptor with a robust binding interface towards a conserved fungal pathogen effector 96%
- PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana 95%
Similar papers in this journal
- High-efficiency, transgene-free plant genome editing by viral delivery of an engineered TnpB 96%
- Stomatal regulators are co-opted for seta development in the astomatous liverwort Marchantia polymorpha 96%
- Dynamic regulation of immunity through post-translational control of defense transcript splicing 96%
Similar papers in this journal
Similar papers in this journal
- Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition 96%
- An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species 96%
- Structure-Function analysis of Lactiplantibacillus plantarum DltE reveals D-alanylated lipoteichoic acids as direct symbiotic cues supporting Drosophila juvenile growth 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.