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Development and cross-tissue validation of a methylation profile score for the cortisol response to stress

2026-02-18 genetic and genomic medicine Title + abstract only
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Hypothalamic-pituitary-adrenal axis (HPA axis) dysregulation is a risk factor for poor mental and physical health. Animal studies indicate that DNA methylation may be one mechanism through which stress can influence the function of the HPA axis, however human studies have not identified consistent individual loci. Machine learning can be used to develop methylation profile scores (MPSs), but this method has not yet been applied to HPA axis function. Using a novel machine learning pipeline, we de...

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