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Bringing calorimetry (back) to life

Khodabandehlou, F.; Maes, C.; Roldan, E.

2026-02-18 biophysics
10.64898/2026.02.16.706158 bioRxiv
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Micro-calorimetry offers significant potential as a quantitative method for studying the structure and function of biological systems, for instance, by probing the excess heat released by cellular or sub-cellular structures, isothermal or not, when external parameters change. We present the conceptual framework of nonequilibrium calorimetry, and as illustrations, we compute the heat capacity of biophysical models with few degrees of freedom related to ciliar motion (rowing model) and molecular motor motion (flashing ratchets). Our quantitative predictions reveal intriguing dependencies of the (nonequilibrium) heat capacity as a function of relevant biophysical parameters, which can even take negative values as a result of biological activity.

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