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Clinical and Pathological Progression of Awareness Trajectories in Preclinical Alzheimer's Disease

2026-02-18 neurology Title + abstract only
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Subtle alterations in awareness may emerge in the preclinical stage of Alzheimers disease (AD), yet their clinical significance and translational relevance remain unclear. This study aimed to evaluate associations of distinct awareness trajectories with clinical and multimodal AD biomarker measurements in cognitively unimpaired (CU) older adults. This prospective study analyzed data from the Anti-Amyloid Treatment in Asymptomatic Alzheimers (A4) and Longitudinal Evaluation of Amyloid Risk and N...

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