A time-to-event heritability framework for inferring the genetic architecture of longitudinal traits

2026-02-22 genetic and genomic medicine Title + abstract only

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Biobanks with longitudinal measurements have advanced our understanding of time-to-event (TTE) traits including age-of-onset and disease progression. However, limited work has characterized the heritability of TTE traits, a key parameter for comparisons of total association and predictive power. Here, we present COXMM, a Cox proportional hazard mixed model for estimating TTE heritability. Simulations show our model achieves nearly unbiased results, whereas non-TTE approaches severely underestima...

A time-to-event heritability framework for inferring the genetic architecture of longitudinal traits

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