Psychological influences on hypertension in Southeastern Nigeria: a mixed-methods study protocol

IntroductionThe Southeastern region of Nigeria faces a severe public health challenge from hypertension due to its high prevalence. Psychological factors such as stress, anxiety, depression, coping mechanisms, and social support play essential roles in hypertension development and treatment, yet there has been limited scholarly attention to these factors in Nigerian and international qualitative research. This study addresses this evidence gap by investigating the psychological factors that influence hypertension development in adults living in Southeastern Nigeria. Materials and methodsThe sequential explanatory mixed methods study includes validated psychometric instruments assessing perceived stress, anxiety, depression, coping mechanisms, and social support. Regression analyses, correlation tests, and mediation/moderation models will be used to examine relationships among these variables. The research team will collect qualitative data through semi-structured interviews accessible to participants either online or in person. Thematic analysis following Braun and Clarkes six-phase framework will be employed to explore participants lived experiences of stress, coping, and hypertension management. Ethics and disseminationEthical approval was obtained from the University of Bradford Research Ethics Committee on 7th August 2025. The research follows all procedures based on the Declaration of Helsinki and institutional ethical guidelines. Findings will be disseminated at academic conferences and published in peer-reviewed journals and stakeholder meetings held in both the UK and Nigeria. The research aims to generate evidence to support the development of comprehensive psychosocial care plans that address both physical and mental aspects of hypertension treatment in areas with limited resources.