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Integrative transcriptomic analysis identifies long noncoding RNA dysregulation and circadian disruption in reward and executive circuits of opioid use disorder
2026-02-17
genetic and genomic medicine
Title + abstract only
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Opioid use disorder (OUD) is characterized by compulsive drug seeking and impaired executive control arising from maladaptive plasticity within cortico-striatal circuits. While transcriptomic studies have identified coding gene alterations in the nucleus accumbens (NAc) and dorsolateral prefrontal cortex (DLPFC), the contribution of the noncoding genome remains poorly defined. Here, we performed integrative transcriptomic analysis of postmortem human NAc and DLPFC to systematically identify and ...
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