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Ataraxis: Bridging AI Coding Assistants and Scientific Hardware

Kondratyev, I.; Sun, W.

2026-02-16 neuroscience
10.64898/2026.02.13.705771 bioRxiv
Show abstract

AI coding assistants excel at software tasks but lack structured access to laboratory hardware, the physical instruments that define experimental science. We present AO_SCPLOWTARAXISC_SCPLOW, an open-source framework that provides hardware control capabilities spanning camera acquisition, microcontroller communication, precision timing, and inter-process coordination, while exposing these capabilities to AI agents through Model Context Protocol (MCP) servers and domain-specific skills. Critically, AO_SCPLOWTARAXISC_SCPLOW separates configuration-time AI assistance from runtime data acquisition, ensuring that experiments run deterministically regardless of AI service availability. We validate this architecture in a two-photon imaging and virtual reality rodent behavior platform, demonstrating up to order-of-magnitude reductions in hardware validation, integration, and personnel onboarding time. By bridging the gap between AI software capabilities and physical instrument control, AO_SCPLOWTARAXISC_SCPLOW offers a reusable blueprint for AI-assisted scientific instrumentation across experimental disciplines. All code is available at github.com/Sun-Lab-NBB/ataraxis.

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