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Parsing Neurometabolic Signatures of Multiple Sclerosis with MRSI and cPCA
2026-02-16
radiology and imaging
Title + abstract only
View on medRxiv
Show abstract
Magnetic Resonance Spectroscopy Imaging (MRSI) offers spatially-resolved, neurometabolic information, acquired non-invasively at whole-brain scales from human subjects. Analysis of MRSI however, is extremely challenging. The metabolic information is highly convolved, and sparsely distributed across millions of spatial-spectral datapoints, allowing for little direct human interpretation. Conversely, the overall low signal-to-noise with high-intensity artifacts can confound unsupervised machine le...
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