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Decoding the metabolic blockade effect: PFAS inhibition of organic anion transporters impairs VOC clearance and amplifies neurocognitive decline
2026-02-15
occupational and environmental health
Title + abstract only
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The co-occurrence of per- and polyfluoroalkyl substances (PFAS) and volatile organic compounds (VOCs) in industrial environments poses complex toxicological risks that standard additive models fail to capture. This study elucidates a novel "metabolic blockade" mechanism wherein PFAS competitively inhibits the renal excretion of VOC metabolites, thereby amplifying neurotoxic burdens. Utilizing a Double Machine Learning (DML) framework on data from National Health and Nutrition Examination Survey ...
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