Back

Neuronal DNA repair mediates systemic mitochondrial maintenance through acetylcholine signaling

da Silva, P.; Ropert, B.; Rieckher, M.; Rive, C.; Schumacher, B.

2026-02-12 genetics
10.64898/2026.02.11.705232 bioRxiv
Show abstract

DNA repair defects such as Nucleotide Excision Repair (NER) mutations can lead to progeroid syndromes characterized by growth retardation and accelerated aging with distinct tissue type specific pathologies. DNA damage induced dysfunction of specific cell types can impair the organisms overall function. It is unknown whether, in reverse, DNA repair in specific tissues can have non-cell-autonomous consequences on other tissues carrying DNA damage. To explore the organismal consequences of cell type specific DNA repair, we restricted NER activity to specific tissues and monitored consequences on organismal health in C. elegans. Unexpectedly, we observed that tissue specific DNA repair is sufficient to improve overall DNA damage resistance. Strikingly, the sole NER activity in neurons is sufficient to provide similar overall DNA damage resistance as whole body NER. We show that this systemic DNA damage resilience is mediated by neuronal Acetylcholine signaling that promotes the maintenance of mitochondrial activity throughout the organism.

Matching journals

The top 4 journals account for 50% of the predicted probability mass.

50% of probability mass above

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.