Back

High-Sensitivity Radiation-Free Triage for Adolescent Idiopathic Scoliosis via 3D Point Cloud Geometry

Yang, J.; Shi, H.; Huang, Z.; Wang, X.; Wang, W.; Zhang, T.; Wang, J.; Zhan, Y.; Liu, H.; Zhang, Z.; Zhang, J.; Fei, Z.; Xuan, X.; Gao, Y.; Deng, Y.; Wang, L.; Liu, X.; Tian, L.; Zhang, Y.; Ai, L.; Yang, J.

2026-03-16 public and global health
10.64898/2026.02.11.26346069 medRxiv
Show abstract

Widespread screening for Adolescent Idiopathic Scoliosis (AIS) is critical for early intervention, yet it is currently bottlenecked by the inherent limitations of traditional methods. Radiographic diagnosis poses cumulative radiation risks, while manual physical examinations are highly subjective and time-consuming. Recent non-invasive 2D computer vision approaches suffer from an unavoidable "dimensionality gap," failing to capture critical depth and rotational information, which frequently leads to diagnostic misjudgments. To address these challenges, we present PointScol, a high-sensitivity, radiation-free triage system leveraging direct geometric processing of 3D back surface point clouds. Our framework employs a sequential pipeline: first, an automated segmentation module rigorously standardizes the input geometry by isolating the dorsal region of interest; subsequently, a diagnostic classification module evaluates the spinal deformity. Validation on a multi-center dataset (n=128) demonstrated that for the primary screening task (10{degrees} Cobb angle threshold), PointScol achieved 100.00% sensitivity in the external cohort, acting as a reliable gatekeeper to safely rule out healthy individuals without missing any cases requiring referral. Building upon the robust accuracy established at this 10{degrees} baseline, an extended 5-class grading module provides further diagnostic value. Rather than functioning as a rigid predictive task, this multi-class stratification acts as an advanced clinical assistant, offering nuanced severity insights to guide referral urgency and optimize medical resource allocation for high-risk patients. Collectively, this sequential design establishes PointScol as a safe and highly efficient clinical filter: it reliably prevents unnecessary radiation exposure for healthy adolescents while ensuring prioritized interventions for those most in need.

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
Nature Communications
4913 papers in training set
Top 7%
17.8%
2
eLife
5422 papers in training set
Top 5%
10.3%
3
npj Digital Medicine
97 papers in training set
Top 0.6%
8.5%
4
PLOS ONE
4510 papers in training set
Top 23%
7.3%
5
Scientific Reports
3102 papers in training set
Top 13%
6.9%
50% of probability mass above
6
Nature Medicine
117 papers in training set
Top 0.3%
6.5%
7
Science Advances
1098 papers in training set
Top 3%
4.4%
8
Proceedings of the National Academy of Sciences
2130 papers in training set
Top 23%
3.1%
9
Communications Biology
886 papers in training set
Top 6%
1.9%
10
Nature Methods
336 papers in training set
Top 4%
1.9%
11
Journal of The Royal Society Interface
189 papers in training set
Top 3%
1.5%
12
PLOS Digital Health
91 papers in training set
Top 2%
1.4%
13
Frontiers in Medicine
113 papers in training set
Top 5%
1.1%
14
Journal of Neural Engineering
197 papers in training set
Top 2%
1.0%
15
IEEE Transactions on Medical Imaging
18 papers in training set
Top 0.4%
1.0%
16
Cell Reports Medicine
140 papers in training set
Top 6%
0.9%
17
PLOS Computational Biology
1633 papers in training set
Top 22%
0.9%
18
JAMA Network Open
127 papers in training set
Top 4%
0.8%
19
iScience
1063 papers in training set
Top 31%
0.8%
20
Swiss Medical Weekly
12 papers in training set
Top 0.3%
0.8%
21
Genome Medicine
154 papers in training set
Top 8%
0.8%
22
Nano Letters
63 papers in training set
Top 3%
0.7%
23
Emerging Infectious Diseases
103 papers in training set
Top 3%
0.7%
24
Clinical Infectious Diseases
231 papers in training set
Top 5%
0.7%
25
IEEE Access
31 papers in training set
Top 1%
0.7%
26
Annals of Internal Medicine
27 papers in training set
Top 1%
0.5%
27
The Lancet Infectious Diseases
71 papers in training set
Top 4%
0.5%