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Lower mitochondrial DNA abundance in blood cells is associated with higher general morbidity and all-cause mortality: a 30-year prospective epidemiological study
2026-02-11
epidemiology
Title + abstract only
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BackgroundLow mitochondrial DNA (mtDNA) abundance in blood cells has been associated with various diseases and major causes of mortality. However, the causal link and molecular mechanisms involved remain unclear, and previous studies have had limited follow-up durations. To address these gaps, we examined the relationship of blood mtDNA abundance with all-cause and cause-specific mortality over three decades, and integrated blood transcriptomic profiling to explore underlying molecular mechanism...
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