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Data-Driven Multimodal Subtyping Reveals Differential Cognitive Risk and Treatment Effects in the All of Us Cohort

2026-02-11 neurology Title + abstract only
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BackgroundCognitively unimpaired (CU) adults vary substantially in their risk of developing mild cognitive impairment (MCI), yet most subtyping approaches focus on downstream neurobiological or cognitive markers rather than upstream, modifiable risk factors. We aimed to identify clinically meaningful subgroups of CU adults defined by integrated comorbid, behavioral, and social risk profiles, and to evaluate heterogeneity in both incident MCI risk and cardiometabolic treatment effects. MethodsWe...

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