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Circulating Senescence Protein Links Exercise Adaptation to Health Outcomes
2026-02-12
geriatric medicine
Title + abstract only
View on medRxiv
Show abstract
Adaptation to physiological stress is fundamental to health but varies widely among individuals. In humans, this heterogeneity is evident in markedly different gains in fitness in response to identical exercise training. The molecular determinants of this variable "trainability" remain poorly understood. Here we identify insulin-like growth factor binding protein-7 (IGFBP7), a senescence-associated secreted protein, as a circulating constraint on exercise adaptation. Plasma proteomics in older a...
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