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Genomic partitioning of Alzheimer's disease in humans reveals non-CNS etiology

2026-02-11 genetic and genomic medicine Title + abstract only
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Alzheimers disease (AD) is marked by hallmark neuropathological changes in the brain. However, its upstream genetic determinants, beyond the central nervous system (CNS), remain largely unexplored. To that extent, we integrated human genomic data with cross-tissue and single-cell analyses across up to 40 peripheral tissues and 100 brain regions. We observed limited genetic enrichment in the CNS, with brain-resident microglia emerging as the sole enriched cell type. Instead, AD risk loci were pre...

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