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A Biopsychosocial Risk Score for Stratifying Disease Vulnerability in Healthy Populations: A Prospective Cohort and Multi-Omics Study in the UK Biobank

2026-02-10 public and global health Title + abstract only
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Proactive identification of systemic vulnerability for disease(s) before clinical onset in healthy individuals is an ultimate goal of preventive and precision medicine, yet current tools remain largely disease-specific and fail to quantify latent vulnerability, an integrative measure of underlying health status, for early prevention and risk-stratified intervention. To address this, we developed the Risk Score for Disease Vulnerability (RS4DV) based on 85 accessible biopsychosocial measures, whi...

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