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Predictive Value of Plasma P-tau217 and APOE Genotype for Preclinical Cognitive Decline in Alzheimer's Disease

2026-02-09 neurology Title + abstract only
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BackgroundAPOE-{rho}.4 is the strongest genetic risk factor for Alzheimers disease (AD), and plasma phosphorylated tau217 (P-tau217) is a highly sensitive and specific biomarker for AD pathology. Their combined utility to predict cognitive decline before onset of AD has not been systematically evaluated. MethodsUsing longitudinal data from multiple cohorts, we evaluated plasma P-tau217 as a predictor of when cognitive impairment occurs in AD. P-tau217 concentrations were analyzed as continuous ...

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