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A Novel Drug-Drug Interaction: Dihydropyridine Calcium Channel Blockers Amplify Gabapentin-Associated Dementia Risk

2026-02-09 pharmacology and therapeutics Title + abstract only
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BackgroundGabapentin prescriptions have increased 123% since 2010, reaching 15.5 million Americans annually. Recent studies suggest gabapentin-dementia associations, but whether concomitant medications modify this risk is unknown. Both gabapentin and calcium channel blockers (CCBs) affect neuronal calcium signaling through distinct mechanisms, raising the possibility of pharmacodynamic interaction. MethodsActive comparator new-user cohort study using Rutgers Clinical Research Data Warehouse (20...

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